Roth J, Mährlein W, Krause M, Harzbecker K
Z Erkr Atmungsorgane. 1978 Mar;150(3):268-78.
Investigations for dose-effect relationship of acetylcholine-ultrasonic-aerosols (apparatus "TUR" USI3, duration of inhalation three minutes, control of the ventilation parameters five minutes after termination of inhalation) led to the result that the delimination of the bronchial hyperreactivity is already possible by application of a 0.01% test-concentration. In this way the ultrasonic-aerosol-method also leads to results which are comparable with the nozzle-aerosol-method used in GDR (0.5% test-concentration, duration of inhalation one minute). As a limiting criteria for the evaluation of a bronchial hyperreactivity analogous to the decrease in the FEV1 of greater than or equal to 15% in comparison with the starting position for the bodyplethysmography yield an increase of the resistance totalis of greater than or equal to 3.0 cm H2O/1/s.
对乙酰胆碱超声气雾剂剂量效应关系的研究（“TUR”USI3仪器，吸入持续三分钟，吸入终止五分钟后控制通气参数）得出的结果是，通过应用0.01%的测试浓度已经可以界定支气管高反应性。这样，超声气雾剂法也得出了与民主德国使用的喷嘴气雾剂法（0.5%测试浓度，吸入持续一分钟）可比的结果。作为评估支气管高反应性的一个限制标准，类似于与体容积描记法起始位置相比FEV1下降大于或等于15%，得出总阻力增加大于或等于3.0 cm H2O/1/s。
