Antonaci S, Jirillo E, Silvestris F, Lucivero G, Fumarola D, Bonomo L
Prostaglandins Leukot Med. 1982 Sep;9(3):285-93. doi: 10.1016/s0262-1746(82)80015-2.
The modulating effects of Prostaglandin E2, solubilized in medium, were observed in the antibody-dependent cytotoxic system. The pretreatment of effector cells with PGE2 up to 5 hours increased significantly the cytotoxic activity. The enhancement was distributed in both Non-T and T lymphocyte fractions suggesting a more pronounced activation of K cells. The effect was abrogated by pretreating lymphocyte suspensions with Indomethacin before exposure to prostaglandin. On the other hand, the addition of PGE2 during the test led to an inhibition of the cytotoxic capacity. Taken together, these results imply either a relationship between endogenously produced PGE2 and the concentration of exogenous PGE2 or the influence of PGE2 on microenvironment (i. e. exchange of calcium and magnesium through the cell membrane) during the cytolytic phenomenon.
在抗体依赖性细胞毒性系统中观察了溶解于培养基中的前列腺素E2的调节作用。用PGE2预处理效应细胞长达5小时可显著提高细胞毒性活性。这种增强作用在非T淋巴细胞和T淋巴细胞组分中均有分布，表明K细胞的激活更为明显。在用前列腺素处理之前，用吲哚美辛预处理淋巴细胞悬液可消除这种作用。另一方面，在试验过程中添加PGE2会导致细胞毒性能力受到抑制。综上所述，这些结果表明内源性产生的PGE2与外源性PGE2的浓度之间存在某种关系，或者PGE2在细胞溶解现象期间对微环境有影响（即通过细胞膜交换钙和镁）。
