Kätzel R, Kubel M, Scheel H, Wegner H
Z Gesamte Inn Med. 1978 Aug 1;33(15):525-9.
Seven patients with haemophilia A CP were injected in a dosage of 1 to 3 double units, which were stored for 127 days partly deep-frozen, partly lyophilized and after this time contained fibrinogen fission products (16--256 microgram/ml). Though in two patients after the transfusion positive WA of the injected fibrinogen fission products were established, a relevant influence on the fibrinogen fission product levels of the patients is to be expected only after administration of larger quantities of such preparations. The therapeutic efficacy of the stored CP was insufficient, since despite good in-vitro-activities of factor VIII the increase of factor VIII in four patients was slight and retarding and did not take place in three patients.
7例甲型血友病慢性期患者接受了1至3个双单位的注射，这些制剂部分深冻、部分冻干保存了127天，此时含有纤维蛋白原裂解产物（16 - 256微克/毫升）。尽管两名患者输血后检测到所注射纤维蛋白原裂解产物的华氏反应呈阳性，但预计只有在给予大量此类制剂后才会对患者的纤维蛋白原裂解产物水平产生显著影响。储存的冷沉淀治疗效果不佳，因为尽管因子VIII的体外活性良好，但4例患者的因子VIII增加轻微且延迟，3例患者未出现增加。
