Scholten T, Fritsch W P, Müller J E, Hengels K J
Scand J Gastroenterol Suppl. 1982;72:169-71.
H2-receptor-antagonists inhibit pentagastrin-stimulated acid secretion for a longer period than basal secretion. Anticholinergic drugs and pirenzepine are less effective and act differently by reduction of volume. Acid concentration is reduced to 95% by cimetidine compared to 20% by atropine and pirenzepine. By increasing electrical vagal stimulation there is a decreasing effect of cimetidine. In contrast, atropine and pirenzepine inhibit vagally transmitted acid secretion by about 45%, even when vagally stimulated acid secretion amounts to more than 50% of the pentagastrin-stimulated secretion. These results support the hypothesis of histaminergic and cholinergic receptors in man.
H2受体拮抗剂抑制五肽胃泌素刺激的胃酸分泌的时间比基础分泌更长。抗胆碱能药物和哌仑西平效果较差，且通过减少分泌量发挥不同作用。与阿托品和哌仑西平使胃酸浓度降低20%相比，西咪替丁可将胃酸浓度降低至95%。增加迷走神经电刺激时，西咪替丁的作用减弱。相比之下，即使迷走神经刺激引起的胃酸分泌量超过五肽胃泌素刺激分泌量的50%，阿托品和哌仑西平仍可抑制约45%的迷走神经传导性胃酸分泌。这些结果支持人体内存在组胺能和胆碱能受体的假说。
