Lederer P C, Thiemann R, Femppel J, Domschke W, Lux G
Scand J Gastroenterol Suppl. 1982;72:131-7.
The present study was performed to investigate the correlation between gastric H-ion-concentration and interdigestive motility (1) under basal conditions and (2) under the influence of pirenzepine, atropine and cimetidine. During the control period 6.5 (DZ1 5, DZ9 12) MMC's per 12-hour periods (69 +/- 7% gastrointestinal MMC's) were recorded. After administration of pirenzepine and the combination of pirenzepine and cimetidine almost exclusively gastrointestinal MMC's could be identified. On the other hand, atropine did not change the gastrointestinal/intestinal MMC ratio, but reduced total number of MMC's significancy (p less than 0.05). Percentage of observation time with antral pH greater than 4 was significantly increased by the combination of pirenzepine and cimetidine, but not by pirenzepine or cimetidine alone nor by atropine. There was a positive correlation between interdigestive cycle-length and percentage of time with antral pH greater than 4. The effect of pirenzepine on interdigestive motility (1) seems not to be mediated by the inhibition of gastric acid and (2) is different from the effect of atropine.
本研究旨在探讨（1）基础状态下以及（2）在哌仑西平、阿托品和西咪替丁影响下胃氢离子浓度与消化间期动力之间的相关性。在对照期，每12小时记录到6.5次（DZ1为5次，DZ9为12次）移行性复合运动（MMC）（占胃肠道MMC的69±7%）。给予哌仑西平以及哌仑西平和西咪替丁联合用药后，几乎只能识别出胃肠道MMC。另一方面，阿托品并未改变胃肠道/肠道MMC的比例，但显著降低了MMC的总数（p<0.05）。哌仑西平和西咪替丁联合用药显著增加了胃窦pH值大于4的观察时间百分比，但单独使用哌仑西平或西咪替丁以及阿托品均未出现这种情况。消化间期时长与胃窦pH值大于4的时间百分比之间存在正相关。哌仑西平对消化间期动力的影响（1）似乎不是通过抑制胃酸介导的，（2）且与阿托品的作用不同。
