Cheli R, Giacosa A, Molinari F
Scand J Gastroenterol Suppl. 1982;72:221-4.
Long term pirenzepine treatment of duodenal ulcer patients was carried out. Full dose pirenzepine therapy (100 mg/day) for 28 days resulted in 34 (77%) out of 44 duodenal ulcer patients with endoscopically healed lesions. Sixteen of them, randomly chosen, were treated with low pirenzepine doses (50 mg/day) for 6 months with evidence of clinical and endoscopic ulcer relapse in 3 cases (18.7%); while in 16 subjects who interrupted the treatment completely, evidence of clinical recurrence in 11 (68.7%) and of endoscopic recurrence in 10 (62.5%) within the following six months. The statistical analysis failed to reveal significant differences between treated and not treated patients. These data were compared with what observed after interruption of treatment in 16 patients whose duodenal ulcer previously healed after 28 days of antacid therapy. Clinical ulcer recurrence in up to 6 months were shown in 9 (56.2%) of them, and endoscopic relapses were shown in 7 (43.7%). In conclusion, the maintenance therapy with low doses of pirenzepine reduces the number of ulcer relapses when compared with pirenzepine withdrawal or with antacid withdrawal, even though this difference is not statistically significant.
对十二指肠溃疡患者进行了长期的哌仑西平治疗。44例十二指肠溃疡患者接受全剂量哌仑西平治疗（100毫克/天）28天，其中44例中有34例（77%）内镜检查显示溃疡病变愈合。随机选择其中16例患者，给予低剂量哌仑西平（50毫克/天）治疗6个月，3例（18.7%）出现临床和内镜检查溃疡复发；而在16例完全中断治疗的患者中，在接下来的6个月内，11例（68.7%）出现临床复发，10例（62.5%）出现内镜复发。统计分析未显示治疗组和未治疗组患者之间存在显著差异。将这些数据与16例十二指肠溃疡患者在接受抗酸剂治疗28天后溃疡先前已愈合、之后中断治疗后的观察结果进行比较。其中9例（56.2%）在长达6个月内出现临床溃疡复发，7例（43.7%）出现内镜复发。总之，与停用哌仑西平或停用抗酸剂相比，低剂量哌仑西平维持治疗可减少溃疡复发的次数，尽管这种差异无统计学意义。
