Petrillo M, Bianchi Porro G
Hepatogastroenterology. 1980 Oct;27(5):369-71.
Twenty-eight patients with healed duodenal ulcer completed a 12-month double-blind trial to compare the effects of pirenzepine (25 mg twice daily) and placebo on the prevention of duodenal ulcer relapse. Seven of those on pirenzepine had endoscopically proven recurrent ulcer within a mean of 5 months, while 9 of those on placebo had one after a mean of 5.7 months (n.s.). No untoward effects which could be attributed to the drug were observed during the whole period of treatment.
28例十二指肠溃疡已愈合的患者完成了一项为期12个月的双盲试验，以比较哌仑西平（每日两次，每次25毫克）和安慰剂预防十二指肠溃疡复发的效果。服用哌仑西平的患者中有7例在平均5个月内内镜检查证实溃疡复发，而服用安慰剂的患者中有9例在平均5.7个月后出现溃疡复发（无显著性差异）。在整个治疗期间未观察到可归因于该药物的不良反应。
