Beck O A, Witt E, Lehmann H U, Hochrein H
Z Kardiol. 1978 Aug;67(8):522-6.
The influence of the calciumantagonistic agent Gallopamile (D 600) on cardiac conduction and sinus node function was studied by using His bundle recordings and atrial stimulation in 13 patients with normal sinus rhythm. Intravenous administration of a single dose of 4 mg produced a significant increase in the atrioventricular conduction time by 30 %. On atrial stimulation second degree a-v block occurred at lower stimulation rates in all patients after Gallopamile. The impulse propagation in atrial tissue and within the His-Purkinje system was not affected, even in patients with diseased conduction system. There was an impairment in sinus node automaticity, the sinus node recovery time was increased by 58 % of the control value.
采用希氏束记录和心房刺激法，对13例窦性心律正常的患者研究了钙拮抗剂加洛帕米（D 600）对心脏传导和窦房结功能的影响。静脉注射单剂量4mg可使房室传导时间显著延长30%。加洛帕米给药后，所有患者在较低刺激频率下进行心房刺激时均出现二度房室传导阻滞。即使在传导系统病变的患者中，心房组织和希氏-浦肯野系统内的冲动传导也未受影响。窦房结自律性受损，窦房结恢复时间较对照值增加58%。
