成人多囊肾疾病与主要组织相容性系统之间无连锁关系。

Absence of linkage between adult polycystic kidney disease and the major histocompatibility system.

作者信息

Dyer P A, Watters E A, Klouda P T, Harris R, Mallick N P

出版信息

Tissue Antigens. 1982 Aug;20(2):108-11. doi: 10.1111/j.1399-0039.1982.tb00333.x.

DOI:10.1111/j.1399-0039.1982.tb00333.x

Abstract

Four multiplex families affected with adult polycystic kidney disease were investigated for segregation of the disease with haplotypes bearing HLA-A and B antigens and Bf allotypes. In no case did the disease travel with specific haplotypes within families showing an absence of linkage between the disease and the major histocompatability system. In addition, the disease was not associated with any HLA-A or B antigen or Bf allotype either within or among the families studied.

摘要

对四个患有成人多囊肾病的复合家庭进行了研究，以观察该疾病与携带HLA - A和B抗原以及Bf同种异型的单倍型的分离情况。在所有家庭中，该疾病都没有与特定单倍型一起遗传，这表明该疾病与主要组织相容性系统之间不存在连锁关系。此外，在所研究的家庭内部或家庭之间，该疾病也与任何HLA - A或B抗原或Bf同种异型无关。