Halbhuber K J, Geyer G
Folia Haematol Int Mag Klin Morphol Blutforsch. 1977;104(2):265-70.
By means of mixed agglutination of isolated rat hepatocytes with human group A or rat erythrocytes, both of them were previously trypsinized and sialolyzed, respectively, a hepatocytic N-acetylgalactosamine-receptor was demonstrated. Gal-N-ac specifically inhibits this agglutination. Following oxidation with periodic acid red blood cells no more agglutinate with rat hepatocytes. This agglutination is not related to proteins adsorbed to hepatocytes. The agglutinability of erythrocytes and hepatocytes may bear some relevance to the elimination of old red blood cells.
通过将分离的大鼠肝细胞与人A血型红细胞或大鼠红细胞进行混合凝集（两者分别预先用胰蛋白酶处理和唾液酸酶处理），证明了肝细胞的N-乙酰半乳糖胺受体。N-乙酰半乳糖胺特异性抑制这种凝集。用高碘酸氧化后，红细胞不再与大鼠肝细胞凝集。这种凝集与吸附在肝细胞上的蛋白质无关。红细胞和肝细胞的凝集性可能与衰老红细胞的清除有一定关系。
