慢性氯吉兰治疗对可乐定引起的生长激素反应无影响。
Growth hormone response to clonidine unchanged by chronic clorgyline treatment.
作者信息
Siever L J, Uhde T W, Insel T R, Roy B F, Murphy D L
出版信息
Psychiatry Res. 1982 Oct;7(2):139-44. doi: 10.1016/0165-1781(92)90086-i.
PMID:6959167
Abstract
The growth hormone (GH) response to the alpha 2-adrenergic agonist, clonidine, was determined before and after chronic clorgyline treatment in 10 psychiatric patients. No significant differences emerged in the magnitude of the GH response to clonidine before as compared to after clorgyline. These results do not support the hypothesis that postsynaptic alpha 2-adrenergic responsiveness is enhanced following chronic antidepressant treatment.
摘要
在10名精神科患者中，测定了慢性氯吉兰治疗前后生长激素（GH）对α2 - 肾上腺素能激动剂可乐定的反应。与氯吉兰治疗后相比，治疗前GH对可乐定反应的幅度没有显著差异。这些结果不支持慢性抗抑郁治疗后突触后α2 - 肾上腺素能反应性增强的假说。
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