Luthra U K, Mitra A B, Prabhakar A K, Agarwal S S, Bhatnagar P
Acta Cytol. 1982 Sep-Oct;26(5):619-22.
Cytologic monitoring of the epithelia of the female genital tract in 2,603 women using copper-containing intrauterine devices (Cu IUDs) was carried out, with a detailed cytomorphologic study of the cervical smears. The women were followed-up to a maximum period of 60 months of study. The rate of dysplastic lesions in the initial smears was 2.5%. Grouping the 60 months into five time intervals of one year each, the annual rates of dysplasia at follow-up were 4.2%, 1.6%, 3.8%, 0.9% and 3.0%. The rate of dysplasia development in women with initially negative or inflammatory smears did not change significantly during the five years. No dysplasia progressed to carcinoma during the follow-up period. No difference in the behavior of dysplastic lesions detected at the initial stage as compared to those developing during the course of Cu IUD use was observed during the study. This study indicated that there is no significant risk of an increased incidence of cervical dysplasia or carcinoma development in women using copper-containing IUDs for five years.
对2603名使用含铜宫内节育器（Cu IUD）的女性的女性生殖道上皮进行了细胞学监测，并对宫颈涂片进行了详细的细胞形态学研究。对这些女性进行了最长60个月的随访研究。初始涂片的发育异常病变率为2.5%。将60个月分为五个每年一个的时间间隔，随访期间每年的发育异常率分别为4.2%、1.6%、3.8%、0.9%和3.0%。初始涂片为阴性或炎症性涂片的女性在五年内发育异常的发生率没有显著变化。随访期间没有发育异常进展为癌症。在研究过程中，未观察到初始阶段检测到的发育异常病变与使用Cu IUD过程中发生的发育异常病变在行为上有差异。这项研究表明，使用含铜宫内节育器五年的女性发生宫颈发育异常或癌症的发生率没有显著增加的风险。
