Legha S S, Wang Y M, Mackay B, Ewer M, Hortobagyi G N, Benjamin R S, Ali M K
Ann N Y Acad Sci. 1982;393:411-8. doi: 10.1111/j.1749-6632.1982.tb31279.x.
Our data indicate that alpha-tocopherol used in an oral dose of 2 g/m2 daily results in a six- to eightfold increase of the vitamin E levels in serum. The occurrence of congestive heart failure in three patients and the observation of significant pathologic changes in endomyocardial biopsies in approximately half of the patients treated with a median cumulative adriamycin dose level of 550 mg/m2 indicate that alpha-tocopherol does not offer substantial protection against adriamycin-induced cardiac toxicity. The antitumor activity of the drug, however, is not compromised by the concomitant administration of the vitamin.
我们的数据表明，每日口服剂量为2 g/m²的α-生育酚会使血清中维生素E水平提高6至8倍。3名患者出现充血性心力衰竭，并且在接受中位累积阿霉素剂量水平为550 mg/m²治疗的患者中，约有一半的患者心内膜活检观察到明显的病理变化，这表明α-生育酚并不能有效预防阿霉素引起的心脏毒性。然而，该药物的抗肿瘤活性并未因同时服用维生素而受到影响。
