Van Dyke T E, Horoszewicz H U, Genco R J
J Periodontol. 1982 Nov;53(11):682-7. doi: 10.1902/jop.1982.53.11.682.
Neutrophil locomotion was evaluated in three groups of periodontal patients, localized juvenile periodontitis (LJP), post-localized juvenile periodontitis (post-LJP), and generalized juvenile periodontitis (GJP). This was accomplished using regression line analysis, a new method for analysis of neutrophil locomotion in vitro. Neutrophil random migration, chemotaxis and chemokinesis were measured. The present study demonstrates that neutrophil locomotion is reduced in all three patient groups. The reduction in locomotion of the neutrophils in LJP, GJP and in post-LJP patients is due to a decrease of neutrophil migration in the presence of a chemotactic gradient. Furthermore, this decrease in chemotactic response is likely due to a decrease in rate of migration of the population of neutrophils rather than the existence of a large population of poorly responsive neutrophils. Random migration and chemokinesis of these patients' neutrophils are normal. These findings are consistent with our previous findings that the neutrophil locomotor disturbance in juvenile periodontitis is cell-associated and not due to humoral factors, and that there are a reduced number of chemotactic factor receptors present on the cell surface.
在三组牙周炎患者中评估了中性粒细胞的运动，这三组分别是局限性青少年牙周炎（LJP）、局限性青少年牙周炎后期（post-LJP）和广泛性青少年牙周炎（GJP）。这是通过回归线分析完成的，回归线分析是一种体外分析中性粒细胞运动的新方法。测量了中性粒细胞的随机迁移、趋化性和化学增活现象。本研究表明，所有三组患者的中性粒细胞运动均降低。LJP、GJP和post-LJP患者中性粒细胞运动的降低是由于在趋化梯度存在的情况下中性粒细胞迁移减少。此外，这种趋化反应的降低可能是由于中性粒细胞群体迁移速率的降低，而不是由于存在大量反应性差的中性粒细胞。这些患者中性粒细胞的随机迁移和化学增活现象是正常的。这些发现与我们之前的发现一致，即青少年牙周炎中的中性粒细胞运动障碍与细胞相关，而非体液因素所致，并且细胞表面存在的趋化因子受体数量减少。
