Zafiropoulos G G, Flores-De-Jacoby L, Czerch W, Kolb G, Markitziu A, Havemann K
Department of Periodontology, Philipps University of Marburg, School of Dental Medicine, F. R. Germany.
J Biol Buccale. 1988 Sep;16(3):151-6.
PMN chemotactic function and oxydative metabolism were investigated in 13 patients with rapidly progressive periodontitis (RPP) and 9 patients with localized juvenile periodontitis (LJP) using a chemotaxis assay (CHA), luminol chemiluminescence (CL) and nitroblue-tetrazolium (NBT) tests. In the LJP patients there was a significantly lower CHA than in the RPP patients (less than 40%). Three out of the 13 RPP patients displayed a cell-dependent increase of CHA and in 3, the reduced CHA measured was serum-associated whilst among the 9 LJP patients, a cell-dependent defect of CHA was present in 5 patients, a serum-associated defect in one patient and a combined cell- and serum-associated defect was found in another patient. The average values of CL in the RPP patients were significantly lower (1309.3 +/- 814.2) than those measured in the LJP group (2208 +/- 826.9). In contrast, the mean NBT test values indicated a lower phagocytic function in the LJP patients than in the RPP ones suggesting also the presence of a serum-dependent factor in RPP and that of a combined cell- and serum-response in LJP. According to these results, the neutrophil dysfunction in RPP, as indicated by both the chemotaxis and the oxydative metabolism nature, was frequently associated with a serum factor.
采用趋化试验（CHA）、鲁米诺化学发光（CL）和硝基蓝四氮唑（NBT）试验，对13例快速进展性牙周炎（RPP）患者和9例局限性青少年牙周炎（LJP）患者的中性粒细胞趋化功能和氧化代谢进行了研究。LJP患者的CHA显著低于RPP患者（低于40%）。13例RPP患者中有3例表现出细胞依赖性CHA增加，3例患者测得的CHA降低与血清有关，而9例LJP患者中，5例存在细胞依赖性CHA缺陷，1例存在血清相关缺陷，另1例存在细胞和血清联合相关缺陷。RPP患者的CL平均值（1309.3±814.2）显著低于LJP组（2208±826.9）。相反，平均NBT试验值表明，LJP患者的吞噬功能低于RPP患者，这也提示RPP中存在血清依赖性因子，LJP中存在细胞和血清联合反应。根据这些结果，RPP中的中性粒细胞功能障碍，无论是趋化性还是氧化代谢性质，都常与血清因子有关。
