覆盖人类基因组需要多少个多态性基因？
How many polymorphic genes will it take to span the human genome?
作者信息
Lange K, Boehnke M
出版信息
Am J Hum Genet. 1982 Nov;34(6):842-5.
Abstract
It is desirable to know how many polymorphic marker loci will be required so that every human genetic locus can be mapped by classical pedigree methods to a specific region of a specific chromosome. Assuming a total autosomal map length of 33 morgans, it would take only about 33/(2d) evenly spaced markers for every locus to be within d morgans of a marker. Taking into account that the markers will fall randomly along the genome, we show that a much larger number of such loci will have to be isolated and tested before the goal of a saturated gene map is reached.
摘要
我们希望知道需要多少个多态性标记位点，以便能够通过经典的系谱方法将每个人类基因座定位到特定染色体的特定区域。假设常染色体的总图谱长度为33摩根，那么只需大约33/(2d)个均匀分布的标记，就能使每个基因座都位于距离某个标记d摩根的范围内。考虑到标记会在基因组中随机分布，我们发现，在达到饱和基因图谱的目标之前，必须分离和测试数量多得多的此类位点。
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