Haworth C, Morris-Jones P H, Testa N G
Br J Cancer. 1982 Dec;46(6):918-23. doi: 10.1038/bjc.1982.302.
We have studied granulocyte-macrophage progenitor cells (GM-CFC) in serial bone marrow aspirates from 43 children who had been treated for acute lymphoblastic leukaemia (ALL). All patients were in full remission, not receiving anti-leukaemic therapy and 42 out of the 43 had normal peripheral blood counts. Thirty-seven patients have received standard amounts of chemotherapy and 6 have received additional therapy for relapses occurring in the first treatment-free interval. In the former group estimation of GM-CFC incidence did not provide evidence of long-term residual bone-marrow damage. In the latter, however, the mean incidence of GM-CFC was significantly reduced. This reduction was also apparent when the incidence of GM-CFC was related to the incidence of non-haemopoietic progenitor cells within the marrow (CFU-F).
我们研究了43名接受过急性淋巴细胞白血病（ALL）治疗的儿童的系列骨髓穿刺物中的粒细胞-巨噬细胞祖细胞（GM-CFC）。所有患者均处于完全缓解期，未接受抗白血病治疗，43名患者中有42名外周血细胞计数正常。37名患者接受了标准剂量的化疗，6名患者因在第一个无治疗间隔期出现复发而接受了额外治疗。在前一组中，GM-CFC发生率的估计未提供长期残留骨髓损伤的证据。然而，在后一组中，GM-CFC的平均发生率显著降低。当GM-CFC的发生率与骨髓中非造血祖细胞（CFU-F）的发生率相关时，这种降低也很明显。
