Dunham W B, Zuckerkandl E, Reynolds R, Willoughby R, Marcuson R, Barth R, Pauling L
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7532-6. doi: 10.1073/pnas.79.23.7532.
We have carried out a study of large malignant skin tumors (squamous cell carcinomas) and other lesions in hairless mice (groups of 38-45) intermittently exposed to ultraviolet light over a period of 15 weeks, beginning when the mice were about 10 weeks old. The several groups were given a standard diet with 0%, 0.3%, 5%, and 10% added L-ascorbic acid (vitamin C) throughout the study. No lesions developed in unirradiated control groups. The lesions were counted every 14 days for 4 months, beginning 4 weeks before the end of the period of irradiation. The observed incidence of lesions of several sizes during successive time periods was analyzed by the statistical method recommended by a committee of the International Agency for Research on Cancer. A pronounced effect of vitamin C in decreasing the incidence and delaying the onset of the malignant lesions was observed with high statistical significance.
我们对无毛小鼠（每组38 - 45只）身上的大型恶性皮肤肿瘤（鳞状细胞癌）及其他损伤进行了研究。这些小鼠从约10周龄开始，在15周的时间里间歇性暴露于紫外线下。在整个研究过程中，几个组分别给予添加了0%、0.3%、5%和10% L - 抗坏血酸（维生素C）的标准饮食。未接受照射的对照组未出现损伤。在照射期结束前4周开始，每14天对损伤进行计数，持续4个月。采用国际癌症研究机构一个委员会推荐的统计方法，分析了连续时间段内不同大小损伤的观察发病率。结果观察到维生素C在降低恶性损伤的发病率和延迟其发病方面有显著效果，具有高度统计学意义。
