偶然分枝杆菌对N-甲酰亚胺基硫霉素及几种头孢霉素的体外敏感性
In vitro susceptibility of Mycobacterium fortuitum to N-formimidoyl thienamycin and several cephamycins.
作者信息
Cynamon M H, Palmer G S
出版信息
Antimicrob Agents Chemother. 1982 Dec;22(6):1079-81. doi: 10.1128/AAC.22.6.1079.
Abstract
The comparative in vitro activity of N-formimidoyl thienamycin, cefmetazole, cefoxitin, cefotetan (YM-09330), and moxalactam against 13 isolates of Mycobacterium fortuitum was evaluated by agar dilution susceptibility testing. N-Formimidoyl thienamycin inhibited 10 to 12 strains at 6.25 micrograms/ml, cefmetazole inhibited 12 of 13 strains at 12.5 micrograms/ml, cefoxitin inhibited 11 of 13 strains at 25 micrograms/ml, and cefotetan inhibited 11 of 13 strains at 50 micrograms/ml. Moxalactam was less active than the other compounds tested, inhibiting only 9 of 13 strains at 50 micrograms/ml.
摘要
通过琼脂稀释药敏试验评估了N-甲酰亚胺硫霉素、头孢美唑、头孢西丁、头孢替坦（YM-09330）和拉氧头孢对13株偶然分枝杆菌的体外比较活性。N-甲酰亚胺硫霉素在6.25微克/毫升时抑制10至12株菌，头孢美唑在12.5微克/毫升时抑制13株菌中的12株，头孢西丁在25微克/毫升时抑制13株菌中的11株，头孢替坦在50微克/毫升时抑制13株菌中的11株。拉氧头孢的活性低于其他受试化合物，在50微克/毫升时仅抑制13株菌中的9株。
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