阿莫西林与克拉维酸联合对结核分枝杆菌的体外活性
In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis.
作者信息
Cynamon M H, Palmer G S
出版信息
Antimicrob Agents Chemother. 1983 Sep;24(3):429-31. doi: 10.1128/AAC.24.3.429.
Abstract
The comparative in vitro activity of amoxicillin alone and in combination with clavulanic acid against 15 isolates of Mycobacterium tuberculosis was evaluated by broth dilution susceptibility testing. Amoxicillin inhibited 4 of 15 isolates at 8 micrograms/ml or less but was not bactericidal against any of the isolates at that concentration. Amoxicillin in combination with clavulanic acid was bactericidal for 14 of 15 isolates tested at an amoxicillin concentration of 4 micrograms/ml or less and a clavulanic acid concentration of 2 micrograms/ml or less.
摘要
通过肉汤稀释药敏试验评估了阿莫西林单独使用及与克拉维酸联合使用对15株结核分枝杆菌的体外比较活性。阿莫西林在8微克/毫升及以下浓度时抑制了15株分离菌中的4株，但在该浓度下对任何分离菌均无杀菌作用。阿莫西林与克拉维酸联合使用时，在阿莫西林浓度为4微克/毫升及以下、克拉维酸浓度为2微克/毫升及以下时，对15株受试分离菌中的14株具有杀菌作用。
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