Einerth Y
Acta Obstet Gynecol Scand. 1978;57(4):361-5. doi: 10.3109/00016347809154031.
Fifty-nine patients (age range 18-40 years, mean 28 years) with dysplasia or carcinoma in situ of the cervix uteri were treated with cryosurgery. Healing occurred in 54 patients (91.6%) after one treatment ("double-freeze" technic) and in 2 patients after refreezing. No early or late complications occurred during a follow-up period of 7-37 months. Five of the patients with carcinoma in situ were followed immunologically with determinations of serum TPA (tissue polypeptide antigen), which can be employed as a parameter of malignancy. In all instances, the initially elevated TPA normalized after cryosurgical treatment. Cryosurgery is a simple, painless and safe treatment method in ectocervically localized carcinoma in situ and dysplasia that is particularly suited for out-patient use.
59例子宫颈发育异常或原位癌患者（年龄范围18 - 40岁，平均28岁）接受了冷冻手术治疗。54例患者（91.6%）经一次治疗（“双重冷冻”技术）后痊愈，2例经再次冷冻后痊愈。在7至37个月的随访期内未发生早期或晚期并发症。对5例原位癌患者进行了免疫学随访，检测血清组织多肽抗原（TPA），其可作为恶性肿瘤的一个参数。在所有病例中，冷冻手术后最初升高的TPA均恢复正常。冷冻手术是一种简单、无痛且安全的治疗方法，适用于宫颈外原位癌和发育异常，尤其适合门诊使用。
