Bloch B, Davies A M
S Afr Med J. 1980 Apr 19;57(16):670-4.
A study undertaken to assess the reliability and effectiveness of cryosurgery in cervical intra-epithelial neoplasia is described. During 1 5-year period a total of 416 patients were so treated and the records were studied retrospectively. This study demonstrated that 34% of patients were lost to follow-up, and that 24% of those followed up had residual disease of the cervix. It was therefore concluded that this form of treatment was inadequate for the hospital population concerned. An additional prospective study was undertaken, as a result of which cryosurgery is recommended only if adequate long-term follow-up is ensured, if skilled colposcopic evaluation is available throughout, and if the disease is limited to mild or moderate dysplasia in younger patients.
本文描述了一项旨在评估冷冻手术治疗宫颈上皮内瘤变的可靠性和有效性的研究。在15年期间，共有416例患者接受了该治疗，并对记录进行了回顾性研究。该研究表明，34%的患者失访，在接受随访的患者中，24%存在宫颈残余病变。因此得出结论，对于相关医院的患者群体而言，这种治疗方式并不充分。另外还进行了一项前瞻性研究，结果表明，只有在确保进行充分的长期随访、全程有熟练的阴道镜评估且疾病仅限于年轻患者的轻度或中度发育异常时，才建议使用冷冻手术。
