Wieriks J, Hespe W, Jaitly K D, Koekkoek P H, Lavy U
Scand J Gastroenterol Suppl. 1982;80:11-6.
In pharmacological ulcer models in rats colloidal bismuth subcitrate (CBS) demonstrated anti-ulcer activity. This was neither a result of an acid neutralizing nor of an acid secretion inhibitory effect. Both in vitro and in vivo, an anti-peptic action was found. At low pH CBS precipitates and was shown to form a coating on the gastric wall especially on the ulcer crater. This coating most likely forms a protective barrier to the peptic activity of gastric juice. Low toxicity was seen following chronic daily administration of high doses of CBS for 3 months to rats and 6 months to dogs. Although the blood levels were more elevated in rats, the tissue bismuth levels were comparable in the two species (except for the caecum). The chief bismuth-excreting organs, the kidneys, showed relatively high concentrations, while the brain-concentrations were extremely low in concordance with the absence of nervous system toxicity.
在大鼠的药理学溃疡模型中，枸橼酸铋钾（CBS）表现出抗溃疡活性。这既不是酸中和作用的结果，也不是胃酸分泌抑制作用的结果。在体外和体内均发现了抗胃蛋白酶作用。在低pH值下，CBS会沉淀，并在胃壁尤其是溃疡 crater 上形成一层涂层。这种涂层很可能对胃液的胃蛋白酶活性形成一种保护屏障。对大鼠连续3个月、对狗连续6个月每日给予高剂量CBS后，观察到低毒性。尽管大鼠的血铋水平升高得更多，但两种动物的组织铋水平相当（盲肠除外）。主要的铋排泄器官肾脏显示出相对较高的浓度，而脑浓度极低，这与无神经系统毒性一致。
