风湿性疾病中的抗疟药。

Antimalarials in rheumatic diseases.

作者信息

Day R O, Sambrook P, Champion G D, Graham G G

出版信息

Aust N Z J Med. 1982 Dec;12(6):645-9. doi: 10.1111/j.1445-5994.1982.tb02658.x.

DOI:10.1111/j.1445-5994.1982.tb02658.x

Abstract

The use of antimalarials in rheumatoid arthritis (RA) and systemic lupus erythematosis (SLE) has declined over recent years due to concern over retinal toxicity and the impression that this class of drugs is relatively ineffective in rheumatic diseases. Recent reviews suggest that this position should be changed. Firstly, there is now good evidence for the efficacy of these drugs in RA and secondly strict control of the daily dosage and careful ophthalmological surveillance can almost eliminate the risk of serious retinal toxicity.

摘要

近年来，由于担心视网膜毒性以及认为这类药物在风湿性疾病中相对无效，抗疟药在类风湿关节炎（RA）和系统性红斑狼疮（SLE）中的使用有所减少。最近的综述表明，这一立场应该改变。首先，现在有充分证据证明这些药物在类风湿关节炎中的疗效，其次，严格控制每日剂量并进行仔细的眼科监测几乎可以消除严重视网膜毒性的风险。