来自加利利链霉菌MA144-M1两个阻断突变体的新型蒽环酮代谢产物。
New anthracyclinone metabolites from two blocked mutants of Streptomyces galilaeus MA144-M1.
作者信息
Tobe H, Yoshimoto A, Ishikura T, Naganawa H, Takeuchi T, Umezawa H
出版信息
J Antibiot (Tokyo). 1982 Dec;35(12):1641-5. doi: 10.7164/antibiotics.35.1641.
PMID:6962794
Abstract
Two blocked mutants of the aclacinomycin-producing Streptomyces galilaeus MA144-M1 produced new anthraquinones and anthracyclinones. The mutant ANR-58 produced compounds 58A, 58B, 58C (7-deoxy-2-hydroxyaklavinone), 58D (2-hydroxyaklavinone) and 58WR. All these compounds have the 2-hydroxyl group. The mutant ANR-665 produced compounds 665A and 665B. The compounds 58A, 58B and 665A have an anthraquinone skeleton.
摘要
产阿克拉霉素的加利利链霉菌MA144-M1的两个阻断突变体产生了新的蒽醌和蒽环酮。突变体ANR-58产生了化合物58A、58B、58C（7-脱氧-2-羟基阿克拉酮）、58D（2-羟基阿克拉酮）和58WR。所有这些化合物都含有2-羟基。突变体ANR-665产生了化合物665A和665B。化合物58A、58B和665A具有蒽醌骨架。
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