Kydd J, Miller J, Antczak D F, Allen W R
J Reprod Fertil Suppl. 1982;32:361-9.
The maternal immunological response to the developing equine fetus was investigated in 69 pregnancies of various genotypes. In normal intraspecies horse pregnancy (N = 16), 94% of mares produced strong cytotoxic antibody responses to paternal histocompatibility antigens which were first detectable between 44 and 70 days after ovulation. In all other types of pregnancy examined (intraspecies donkey, N = 19; interspecies mule, N = 6; interspecies hinny, N = 2; extraspecies horse-in-donkey, N = 3; and extraspecies donkey-in-horse, N = 21), antibody production was observed less frequently, and sometimes with a more irregular onset. However, the dominant pattern of response was similar to that observed in intraspecies horse pregnancy. Although the development of cytotoxic antibody correlated well with the formation of the equine endometrial cups, histological and serological evidence demonstrated that the accumulation of lymphocytes which occurs around the endometrial cups in intra- and interspecies pregnancies, and in the endometrial stroma in contact with trophoblast in extraspecies donkey-in-horse pregnancies which lack endometrial cups, can occur in the absence of a detectable cytotoxic antibody response. The cytotoxic antibody produced by mares carrying extraspecies donkey conceptuses appeared to be directed primarily against donkey alloantigens, and not species-specific antigens, emphasizing the importance of maternal recognition of paternally derived fetal histocompatibility antigens during equine pregnancy.
在69例不同基因型的妊娠中，研究了母马对发育中的马胎儿的免疫反应。在正常的种内马妊娠（N = 16）中，94%的母马对父本组织相容性抗原产生强烈的细胞毒性抗体反应，这种反应在排卵后44至70天之间首次可检测到。在检查的所有其他类型的妊娠中（种内驴妊娠，N = 19；种间骡妊娠，N = 6；种间驴骡妊娠，N = 2；种外马怀驴妊娠，N = 3；种外驴怀马妊娠，N = 21），抗体产生的频率较低，且有时起始更不规律。然而，主要的反应模式与种内马妊娠中观察到的相似。虽然细胞毒性抗体的产生与马子宫内膜杯的形成密切相关，但组织学和血清学证据表明，在种内和种间妊娠的子宫内膜杯周围以及在缺乏子宫内膜杯的种外驴怀马妊娠中与滋养层接触的子宫内膜基质中发生的淋巴细胞聚集，可在没有可检测到的细胞毒性抗体反应的情况下出现。怀有杂种驴胎儿的母马产生的细胞毒性抗体似乎主要针对驴的同种异体抗原，而非物种特异性抗原，这强调了母马在马妊娠期间识别父本来源的胎儿组织相容性抗原的重要性。
