Anniko M, Van de Water T R, Nordemar H
Acta Otolaryngol. 1978 Jul-Aug;86(1-2):52-5. doi: 10.3109/00016487809124719.
The 16th day mouse embryo inner ear was explanted and cultured "in vitro" for 6 days, which corresponds to 1 day post-partum development "in vivo". A normal development occurred both when the inner ear anlage was divided into a vestibular and a cochlear portion and when it was cultured as a whole. The present model system may provide a helpful tool in the study of both normal development and inner ear pathology.
取出第16天的小鼠胚胎内耳并“体外”培养6天，这相当于“体内”产后发育1天。当内耳原基被分为前庭部分和耳蜗部分以及将其作为一个整体培养时，均发生了正常发育。目前的模型系统可能为正常发育和内耳病理学研究提供一个有用的工具。
