Rodger F C
Trans Ophthalmol Soc U K (1962). 1982 Apr;102 (Pt 1):187-97.
In a project which lasted 18 years, the natural history of five common macular lesions was followed in 268 patients, and the most significant clinical features selected in each. Methodology consisted of trichromatic analysis with direct ophthalmoscopy, contact lens fundoscopy including the triple mirror, refraction, and fundus photography. In several subjects in each group repeated fluorescence angiographies were carried out. Single eye records were kept and scattergrams of corrected visual acuities plotted. The latter--besides key clinical features--were then used to predict the probable course. Examples are related both to the biographies and to the clinical features to make the method more comprehensible. The five lesions studied were: cystoid macular degeneration, retinal pigment epithelial detachments, choroidal sclerosis, hyaline degenerations, and macular (foveal) degenerations. A new paramacular 'window' defect called a 'target' lesion is described and attention drawn to its close association with migraine. A feature of the study throughout was the frequency with which more than one of the lesions appeared in the same eye, although there was no set sequence. Thus a patient suffering from one macular lesion not infrequently ended by being blinded by another.
在一个持续了18年的项目中，对268例患者的五种常见黄斑病变的自然病史进行了跟踪研究，并选取了每种病变最显著的临床特征。研究方法包括直接检眼镜的三色分析、包括三面镜的接触镜眼底检查、验光和眼底摄影。每组中的若干受试者进行了重复荧光血管造影。记录单眼情况，并绘制矫正视力散点图。除关键临床特征外，后者随后被用于预测可能的病程。文中列举了与病例及临床特征相关的例子，以使该方法更易于理解。所研究的五种病变为：黄斑囊样变性、视网膜色素上皮脱离、脉络膜硬化、玻璃样变性和黄斑（中心凹）变性。文中描述了一种称为“靶”病变的新的黄斑旁“窗”缺损，并提请注意其与偏头痛的密切关联。整个研究的一个特点是，同一只眼睛中出现一种以上病变的频率，尽管没有固定顺序。因此，患有一种黄斑病变的患者最终往往会因另一种病变而失明。
