Tötterman K J, Turto H, Pellinen T
Acta Med Scand Suppl. 1982;668:28-33. doi: 10.1111/j.0954-6820.1982.tb08519.x.
Four patients with ventricular arrhythmias due to sotalol intoxication were successfully treated with overdrive pacing. In three patients the reason for sotalol overdose was a suicidal attempt and in the fourth patient the reason was unknown. In all cases a prolongation of the Q-T interval was seen, which is a typical feature of sotalol overdose. Other features of beta-blocker intoxication like bradycardia were found in all patients and hypotension in two patients. Three of four patients received lidocaine, but with no effect on multiple ventricular premature beats (VPB) or ventricular tachycardia (VT) of "torsade de pointes"-type. Overdrive pacing abolished immediately VPBs and VTs in three patients, and in the fourth patient there was apparent decrease in dysrhythmia. Temporary overdrive pacing is suggested as treatment of ventricular arrhythmias in association with prolonged Q-T interval caused by overdose of sotalol.
4例因索他洛尔中毒导致室性心律失常的患者经超速起搏治疗成功。3例患者索他洛尔过量的原因是自杀未遂，第4例患者的原因不明。所有病例均可见Q-T间期延长，这是索他洛尔过量的典型特征。所有患者均有β受体阻滞剂中毒的其他特征，如心动过缓，2例患者有低血压。4例患者中有3例接受了利多卡因治疗，但对多源性室性早搏（VPB）或尖端扭转型室性心动过速（VT）无效。超速起搏立即消除了3例患者的VPB和VT，第4例患者的心律失常明显减少。建议将临时超速起搏作为索他洛尔过量导致Q-T间期延长伴发室性心律失常的治疗方法。
