Berkowitz R S, Hornig-Rohan J, Martin-Alosco S, Klein S, Goldstein D P, Bast R C, DeWolf W C
Placenta Suppl. 1981;3:263-7.
HL-A (A,B,C, and DR) antigen frequency distribution was determined in 29 patients with choriocarcinoma and in their husbands, as well as in a matched control population of 21 healthy couples. All 29 patients had achieved complete sustained remission with chemotherapy. The HL-A antigen frequency distribution was normal in the choriocarcinoma patients and in their husbands and there was no abnormal HL-A antigen sharing between patients and their husbands. This study does not exclude the possibility that the pathogenesis of resistant choriocarcinoma may be dependent upon tumour-host histocompatibility.
在29例绒毛膜癌患者及其丈夫以及21对健康夫妇组成的匹配对照人群中，测定了HL - A（A、B、C和DR）抗原频率分布。所有29例患者均通过化疗实现了完全持续缓解。绒毛膜癌患者及其丈夫的HL - A抗原频率分布正常，患者与其丈夫之间不存在异常的HL - A抗原共享。本研究不排除耐药绒毛膜癌的发病机制可能取决于肿瘤与宿主组织相容性的可能性。
