Nékám K, Láng I, Fekete B, Gergely P, Petrányi G
Acta Microbiol Acad Sci Hung. 1978;25(3):191-7.
Dialysable leukocyte extracts significantly inhibited the antibody-dependent cell-mediated cytotoxicity of normal human peripheral blood lymphocytes in both xenogeneic and allogenic assays. The inhibitory effect was dose-dependent. Fractions of dialysable leukocyte extracts separated on Sephadex G-25 column differed in their capacity to suppress cytotoxicity. Dialysable leukocyte extracts did not block EA-rosetting but inhibited the resynthesis of Fc receptors. Some explanations for the observed suppressive effect are discussed.
透析白细胞提取物在异种和同种试验中均显著抑制正常人外周血淋巴细胞的抗体依赖性细胞介导的细胞毒性。抑制作用呈剂量依赖性。在Sephadex G - 25柱上分离的透析白细胞提取物各组分在抑制细胞毒性的能力上有所不同。透析白细胞提取物不阻断EA花环形成，但抑制Fc受体的再合成。文中讨论了对观察到的抑制作用的一些解释。
