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一种非致病性梭菌对恶性胶质瘤的液化(肿瘤溶解)作用

The liquefaction (oncolysis) of malignant gliomas by a non pathogenic Clostridium.

作者信息

Heppner F, Möse J R

出版信息

Acta Neurochir (Wien). 1978;42(1-2):123-5. doi: 10.1007/BF01406639.

DOI:10.1007/BF01406639
PMID:696441
Abstract

Vascular glioblastomas become liquefied when contaminated with spores of the non-pathogenic Clostridium butyricum M 55. The spores are administered by intracarotid injection. The oncolysis is complete one week after injection. The glioblastoma is converted into a brain abscess which is then operated on appropriately. Forty nine patients have been treated in this manner. The rate of recurrence, however, remained uninfluenced.

摘要

血管性胶质母细胞瘤在被非致病性丁酸梭菌M 55的孢子污染时会液化。通过颈动脉注射给予孢子。注射一周后肿瘤溶解完成。胶质母细胞瘤转变为脑脓肿,然后进行适当的手术。已有49名患者接受了这种治疗。然而,复发率并未受到影响。

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本文引用的文献

1
[Therapy of advanced malignant brain tumors].[晚期恶性脑肿瘤的治疗]
Wien Klin Wochenschr. 1966 Jul 1;78(26):482.
2
[Oncolysis of malignant tumors by Clostridium strain M 55].[梭状芽孢杆菌M 55对恶性肿瘤的溶瘤作用]
Med Klin. 1967 Feb 3;62(5):189-93.
3
[Treatment of malignant tumors using spores of Clostridium butyricum M 55. I. Basic principles and development of the influencing of malignant tumors by microorganisms].[利用丁酸梭菌M 55孢子治疗恶性肿瘤。I. 微生物对恶性肿瘤影响的基本原理及进展]
用于益生菌辅助疾病治疗的基因编辑技术进展。
iScience. 2024 Aug 22;27(9):110791. doi: 10.1016/j.isci.2024.110791. eCollection 2024 Sep 20.
4
Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery.梭状芽孢杆菌:利用肿瘤坏死进行靶向基因递送
Mol Diagn Ther. 2024 Mar;28(2):141-151. doi: 10.1007/s40291-024-00695-0. Epub 2024 Feb 2.
5
Hacking the Immune Response to Solid Tumors: Harnessing the Anti-Cancer Capacities of Oncolytic Bacteria.破解实体瘤的免疫反应:利用溶瘤细菌的抗癌能力
Pharmaceutics. 2023 Jul 21;15(7):2004. doi: 10.3390/pharmaceutics15072004.
6
Arginine deiminase produced by lactic acid bacteria as a potent anti-cancer drug.乳酸菌产生的精氨酸脱亚氨酶作为一种有效的抗癌药物。
Med Oncol. 2023 May 12;40(6):175. doi: 10.1007/s12032-023-02043-4.
7
Role of Intravesical BCG as a Therapeutic Vaccine for Treatment of Bladder Carcinoma.膀胱内卡介苗作为膀胱癌治疗性疫苗的作用。
Iran Biomed J. 2022 Nov 1;26(5):340-9. doi: 10.52547/ibj.3676.
8
Bacterial-Based Cancer Therapy (BBCT): Recent Advances, Current Challenges, and Future Prospects for Cancer Immunotherapy.基于细菌的癌症治疗(BBCT):癌症免疫治疗的最新进展、当前挑战及未来前景
Vaccines (Basel). 2021 Dec 18;9(12):1497. doi: 10.3390/vaccines9121497.
9
Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis.溶瘤细菌及其在细菌介导的肿瘤治疗中的潜在作用:概念分析
J Cancer. 2019 Jul 23;10(19):4442-4454. doi: 10.7150/jca.35648. eCollection 2019.
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Arch Geschwulstforsch. 1972;39(3):185-94.
4
[Oncolysis of malignant gliomas through apathogenic clostridia (strain "M 55")].
Zentralbl Neurochir. 1966;27(4):183-92.
5
[The effect of non-pathogenic Clostridia on malignant tumors].[非致病性梭菌对恶性肿瘤的影响]
Z Krebsforsch. 1966;68(4):337-51.