Loc'h C, Mazièré B, Comar D
J Nucl Med. 1980 Feb;21(2):171-3.
To meet the needs created by the rapid development of positron tomographic techniques, a new Ge-68 leads to Ga-68 generator has been developed. By elution under reduced pressure, this tin dioxide/1 N HCl generator provides a sterile solution of Ga-68 in ionic form, ready for use in the preparation of many radiopharmaceuticals. Since the Ga-68 recovery yield is high (75--80%) and the elution time very short (less than 2 min), these products possess maximum activity. Owing to its very slight Ge-68 leakage (less than 0.0002% per elution), the tin dioxide/HCl generator is long-lasting and, more importantly, the radiotoxicity of the labeled derivatives is kept to a minimum. The ionic Ga-68 obtained in this way has been used to label several radiopharmaceuticals.
为满足正电子断层扫描技术快速发展所产生的需求，已研发出一种新型的锗 - 68到镓 - 68发生器。通过减压洗脱，这种二氧化锡/1N盐酸发生器可提供离子形式的无菌镓 - 68溶液，随时可用于制备多种放射性药物。由于镓 - 68的回收率很高（75 - 80%）且洗脱时间非常短（不到2分钟），这些产品具有最大活性。由于其锗 - 68泄漏极少（每次洗脱小于0.0002%），二氧化锡/盐酸发生器使用寿命长，更重要的是，标记衍生物的放射毒性可保持在最低水平。以这种方式获得的离子态镓 - 68已用于标记多种放射性药物。
