Zeglis Brian M, Houghton Jacob L, Evans Michael J, Viola-Villegas Nerissa, Lewis Jason S
Department of Radiology and the Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center , New York, New York, United States.
Inorg Chem. 2014 Feb 17;53(4):1880-99. doi: 10.1021/ic401607z. Epub 2013 Dec 6.
Over the past several decades, radionuclides have matured from largely esoteric and experimental technologies to indispensible components of medical diagnostics. Driving this transition, in part, have been mutually necessary advances in biomedical engineering, nuclear medicine, and cancer biology. Somewhat unsung has been the seminal role of inorganic chemistry in fostering the development of new radiotracers. In this regard, the purpose of this Forum Article is to more visibly highlight the significant contributions of inorganic chemistry to nuclear imaging by detailing the development of five metal-based imaging agents: (64)Cu-ATSM, (68)Ga-DOTATOC, (89)Zr-transferrin, (99m)Tc-sestamibi, and (99m)Tc-colloids. In a concluding section, several unmet needs both in and out of the laboratory will be discussed to stimulate conversation between inorganic chemists and the imaging community.
在过去几十年里，放射性核素已从基本上深奥且处于实验阶段的技术发展成为医学诊断中不可或缺的组成部分。推动这一转变的部分原因是生物医学工程、核医学和癌症生物学方面相互促进的必要进展。无机化学在促进新型放射性示踪剂的开发中所起的开创性作用在一定程度上未得到充分关注。就此而言，本论坛文章的目的是通过详细介绍五种金属基成像剂的开发，更显著地突出无机化学对核成像的重大贡献：（64）Cu - ATSM、（68）Ga - DOTATOC、（89）Zr - 转铁蛋白、（99m）Tc - 司他莫比和（99m）Tc - 胶体。在结论部分，将讨论实验室内外一些未满足的需求，以促进无机化学家和成像领域之间的交流。
