Nakao S, Curthoys I S, Markham C H
Brain Res. 1980 Feb 10;183(2):291-9. doi: 10.1016/0006-8993(80)90465-5.
This study examines projection to the cerebellar flocculus of eye movement-related neurons in the median and paramedian part of the cat pontine tegmentum between the trochlear and the abducens nucleus. They were identified by rhythmic activity related to horizontal vestibular nystagmus induced by sinusoidal rotation. These neurons were classified into several groups by their discharge patterns during nystagmus, using criteria of earlier studies on saccadic eye movements and vestibular nystagmus in the monkey. Electrical stimulation of the ipsilateral flocculus elicited antidromic spike responses in a number of burst-tonic neurons and long-lead and medium-lead burst neurons. These neurons were located in and around the medial longitudinal fasciculus, the nucleus raphe pontis and the nucleus reticularis tegmenti pontis. A few neurons tested were also activated antidromically by stimulation of the contralateral flocculus. In contrast, no pauser neurons were activated from the ipsilateral flocculus. It is concluded that eye movement-related neurons in the medial pontine tegmentum, except for pauser neurons, directly project to the flocculus and may convey information about eye movements of visual and vestibular origins to the flocculus.
本研究考察了猫脑桥被盖部滑车神经核与展神经核之间正中及旁正中部位与眼球运动相关的神经元向小脑绒球的投射。通过与正弦旋转诱发的水平前庭眼震相关的节律性活动来识别这些神经元。利用先前关于猴子扫视眼动和前庭眼震的研究标准，根据这些神经元在眼震期间的放电模式将它们分为几组。对同侧绒球进行电刺激时，许多爆发-紧张型神经元以及长潜伏期和中潜伏期爆发神经元出现了逆向动作电位反应。这些神经元位于内侧纵束、脑桥中缝核和脑桥被盖网状核及其周围。少数被测试的神经元也可被对侧绒球刺激逆向激活。相比之下，同侧绒球并未激活任何停顿型神经元。结论是，脑桥内侧被盖部中与眼球运动相关的神经元，除停顿型神经元外，直接投射至绒球，并可能将视觉和前庭起源的眼球运动信息传递至绒球。
