Williamson A R
Nature. 1980 Feb 7;283(5747):527-32. doi: 10.1038/283527a0.
The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postulate leads to a model explaining ontogenic and evolutionary selection for self recognition, T lymphocyte effector function, the apparent high frequency of alloreactive T cells and immune response gene activity. The model is contrasted with previous explanations of self-recognition phenomena.
有一种假设认为，T淋巴细胞的双重识别是由于两种类型的受体，一种由抗体基因编码，另一种由一个具有简单表达规则的独特多基因家族编码。这一假设引出了一个模型，该模型解释了自我识别的个体发生和进化选择、T淋巴细胞效应功能、同种异体反应性T细胞的明显高频率以及免疫反应基因活性。该模型与先前对自我识别现象的解释形成对比。
