Larson S M, Grunbaum Z, Rasey J S
Radiology. 1980 Mar;134(3):771-3. doi: 10.1148/radiology.134.3.6965545.
The potential usefulness of substrates for glycolysis and nucleic acid synthesis as tumor imaging agents was compared to that of 67Ga-citrate. In separate experiments, 3H-thymidine, 3H-uridine, 14C-2-deoxyglucose, and 67Ga-citrate were injected intraveneously into BALB/c mice with solid subcutaneous EMT-6 sarcomas. For the 3H- and 14C-labeled substrates, absolute uptakes in tumor and tumor-to-blood ratios were as high 1 hour after injection as the comparable maximum values achieved for 67Ga-citrate after 48 hours. These studies suggest that positron-labeled analogues of thymidine, uridine, and 2-deoxyglucose should be useful radiopharmaceuticals for tumor imaging by positron-emission tomography.
将糖酵解和核酸合成的底物作为肿瘤显像剂的潜在效用与枸橼酸镓-67的效用进行了比较。在单独的实验中，将3H-胸腺嘧啶核苷、3H-尿苷、14C-2-脱氧葡萄糖和枸橼酸镓-67静脉注射到患有皮下实体EMT-6肉瘤的BALB/c小鼠体内。对于3H和14C标记的底物，注射后1小时肿瘤的绝对摄取量和肿瘤与血液的比率与48小时后枸橼酸镓-67达到的可比最大值一样高。这些研究表明，胸腺嘧啶核苷、尿苷和2-脱氧葡萄糖的正电子标记类似物应该是用于正电子发射断层扫描肿瘤显像的有用放射性药物。
