Larson S M, Weiden P L, Grunbaum Z, Rasey J S, Kaplan H G, Graham M M, Harp G D, Sale G E, Williams D L
J Nucl Med. 1981 Oct;22(10):869-74.
Uptake [3H] thymidine was studied in BALB/c mice with EMT-6 sarcoma, in Buffalo rats with Morris 7777 hepatoma, and in nine dogs with spontaneous neoplasms: four lymphomas, two osteosarcomas, two soft-tissue sarcomas, and a thyroid carcinoma. High tumor-to-tissue ratios were observed for all tumor types assayed, and absolute uptakes, when computed as percent dose per gram tumor normalized for body weight, were similar for transplanted and spontaneous tumors. In the rodent tumors, radiothymidine was retained for at least 3 hr in the tumor without appreciable loss. In canine neoplasms, although the highest uptakes were observed in cellular tumors with many mitotic figures, tumor uptake showed significant variability that did not correlate with any obvious histologic change, and thus may reflect true biologic differences in metabolism among tumors at different sites in the same animal. These studies provide additional experimental evidence that the ratios of neoplastic to normal tissue and the kinetics of thymidine uptake by tumors are suitable for positron emission tomography of neoplasms in small and large animals, including both transplanted and spontaneous tumors.
在患有EMT - 6肉瘤的BALB/c小鼠、患有Morris 7777肝癌的布法罗大鼠以及9只患有自发性肿瘤的犬（4只淋巴瘤、2只骨肉瘤、2只软组织肉瘤和1只甲状腺癌）中研究了[3H]胸苷的摄取情况。在所检测的所有肿瘤类型中均观察到高肿瘤与组织摄取比，并且当以每克肿瘤的剂量百分比按体重进行归一化计算时，移植瘤和自发瘤的绝对摄取量相似。在啮齿动物肿瘤中，放射性胸苷在肿瘤中保留至少3小时且无明显损失。在犬类肿瘤中，尽管在有许多有丝分裂图像的细胞性肿瘤中观察到最高摄取量，但肿瘤摄取显示出显著变异性，且与任何明显的组织学变化均无相关性，因此可能反映了同一动物不同部位肿瘤代谢的真实生物学差异。这些研究提供了额外的实验证据，即肿瘤组织与正常组织的摄取比以及肿瘤对胸苷的摄取动力学适用于大小动物肿瘤的正电子发射断层扫描，包括移植瘤和自发瘤。
