Larson S M, Weiden P L, Grunbaum Z, Kaplan H G, Rasey J S, Graham M M, Sale G E, Harp G D, Williams D L
J Nucl Med. 1981 Oct;22(10):875-9.
Uptake of [3H]2-deoxyglucose was studied in BALB/c mice with EMT-6 sarcoma, in Buffalo rats with Morris 7777 hepatoma, and in eight dogs with spontaneous neoplasms: five osteosarcomas and three diffuse lymphomas. High tumor-to-tissue ratios were observed for all tumor types studied. In rodents, peak levels of uptake occurred between 30 min and 1 hr, with a slow loss from the tumor of about 10% per hour thereafter. In dogs there was considerable variability in uptake, both between individuals and at different tumor sites within an individual. Necrotic tumor did not take up the radiotracer. Absolute uptakes, when normalized for body weight, were similar for spontaneous and transplanted neoplasms. These studies provide additional support for the concept that positron emission tomography can be used to obtain functional images of important metabolic processes of tumors, including glycolysis.
在患有EMT-6肉瘤的BALB/c小鼠、患有Morris 7777肝癌的布法罗大鼠以及八只患有自发性肿瘤（五只骨肉瘤和三只弥漫性淋巴瘤）的犬中研究了[3H]2-脱氧葡萄糖的摄取情况。在所研究的所有肿瘤类型中均观察到高肿瘤与组织比值。在啮齿动物中，摄取的峰值水平出现在30分钟至1小时之间，此后肿瘤中摄取量以每小时约10%的速度缓慢下降。在犬中，摄取量在个体之间以及个体内不同肿瘤部位之间存在相当大的变异性。坏死肿瘤不摄取放射性示踪剂。当按体重进行归一化时，自发性肿瘤和移植性肿瘤的绝对摄取量相似。这些研究为正电子发射断层扫描可用于获取肿瘤重要代谢过程（包括糖酵解）的功能图像这一概念提供了额外支持。
