Chandra R K
Am J Clin Nutr. 1980 Jan;33(1):13-6. doi: 10.1093/ajcn/33.1.13.
The thymus and spleen of genetically obese (C57BL/6J ob/ob) mice weighed less and contained fewer mononuclear cells and Thy 1.2-positive lymphocytes compared with findings in lean controls. The number of splenic antibody forming cells, particularly IgG-producing lymphocytes, was reduced. There was a marked increase in natural killer cell activity and a slight increase in antibody-dependent cell-mediated cytotoxicity in the obese animals. Cytotoxic response of spleen cells of obese mice immunized in vivo was markedly lower than that of lean controls, whereas the generation of T killer cells against alloantigens after in vitro immunization was unimpaired, which points to a deleterious "microenvironment" in obesity. It is suggested that metabolic, nutritional, and endocrine changes in obesity may contribute to altered immunocompetence.
与瘦素对照小鼠相比，遗传性肥胖（C57BL/6J ob/ob）小鼠的胸腺和脾脏重量较轻，所含单核细胞和Thy 1.2阳性淋巴细胞较少。脾脏抗体形成细胞的数量减少，尤其是产生IgG的淋巴细胞。肥胖动物的自然杀伤细胞活性显著增加，抗体依赖性细胞介导的细胞毒性略有增加。在体内免疫的肥胖小鼠脾细胞的细胞毒性反应明显低于瘦素对照小鼠，而体外免疫后针对同种异体抗原的T杀伤细胞生成未受损害，这表明肥胖存在有害的“微环境”。提示肥胖时的代谢、营养和内分泌变化可能导致免疫能力改变。
