Hayden J H, Rothstein H, Worgul B V, Merriam G R
Experientia. 1980 Jan 15;36(1):116-8. doi: 10.1007/BF02004009.
Exposure to X-rays usually causes cataracts in frogs. These cataracts are always preceded by misalignment of the structures called meridional rows (MR). When cell division is completely halted by hypophysectomy, however, irradiation no longer disturbs the orientation of the MR. Since the MR are the structures formed as lens epithelial cells differentiate into lens fibres it is reasonable to propose that radiocataractogenesis depends upon a mitosis-driven formation of pathological fibres from epithelial cells that have been rendered abnormal by exposure to X-rays.
暴露于X射线通常会导致青蛙患白内障。这些白内障总是在一种叫做子午线排(MR)的结构出现排列不齐之后发生。然而,当通过垂体切除使细胞分裂完全停止时,辐射就不再干扰MR的排列方向。由于MR是晶状体上皮细胞分化为晶状体纤维时形成的结构,因此有理由认为放射性白内障的形成依赖于有丝分裂驱动的、由因暴露于X射线而变得异常的上皮细胞形成病理性纤维。