• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

垂体切除术对青蛙晶状体具有辐射防护作用。

Hypophysectomy exerts a radioprotective effect on frog lens.

作者信息

Hayden J H, Rothstein H, Worgul B V, Merriam G R

出版信息

Experientia. 1980 Jan 15;36(1):116-8. doi: 10.1007/BF02004009.

DOI:10.1007/BF02004009
PMID:6965642
Abstract

Exposure to X-rays usually causes cataracts in frogs. These cataracts are always preceded by misalignment of the structures called meridional rows (MR). When cell division is completely halted by hypophysectomy, however, irradiation no longer disturbs the orientation of the MR. Since the MR are the structures formed as lens epithelial cells differentiate into lens fibres it is reasonable to propose that radiocataractogenesis depends upon a mitosis-driven formation of pathological fibres from epithelial cells that have been rendered abnormal by exposure to X-rays.

摘要

暴露于X射线通常会导致青蛙患白内障。这些白内障总是在一种叫做子午线排(MR)的结构出现排列不齐之后发生。然而,当通过垂体切除使细胞分裂完全停止时,辐射就不再干扰MR的排列方向。由于MR是晶状体上皮细胞分化为晶状体纤维时形成的结构,因此有理由认为放射性白内障的形成依赖于有丝分裂驱动的、由因暴露于X射线而变得异常的上皮细胞形成病理性纤维。

相似文献

1
Hypophysectomy exerts a radioprotective effect on frog lens.垂体切除术对青蛙晶状体具有辐射防护作用。
Experientia. 1980 Jan 15;36(1):116-8. doi: 10.1007/BF02004009.
2
Disorganized meridional rows in the lens epithelium of hypophysectomized frogs (Rana pipiens).垂体切除的青蛙(豹蛙)晶状体上皮中子午线排列紊乱。
Biomedicine. 1976 Jun;25(4):127-30.
3
Modulating radiation cataractogenesis by hormonally manipulating lenticular growth kinetics.通过激素调控晶状体生长动力学来调节辐射性白内障的发生。
Exp Eye Res. 1994 Sep;59(3):291-6. doi: 10.1006/exer.1994.1110.
4
Complete elimination of mitosis and DNA synthesis in the lens of the hypophysectomized frog: effects on cell migration and fiber growth.
Differentiation. 1979;15(3):153-60. doi: 10.1111/j.1432-0436.1979.tb01045.x.
5
G0/G1 arrest of cell proliferation in the ocular lens prevents development of radiation cataract.晶状体中细胞增殖的G0/G1期阻滞可预防放射性白内障的发生。
Ophthalmic Res. 1982;14(3):215-20. doi: 10.1159/000265195.
6
Hypophysial hormones and a G1 block in the lens epithelium of the adult frog (Rana pipiens).成年青蛙(豹蛙)晶状体上皮中的垂体激素与G1期阻滞
Experientia. 1977 Apr 15;33(4):438-9. doi: 10.1007/BF01922197.
7
Hypophysectomy effect on lens epithelium mitosis and galactose cataract development in rats.垂体切除对大鼠晶状体上皮细胞有丝分裂及半乳糖性白内障形成的影响。
Arch Ophthalmol. 1962 Apr;67:476-82. doi: 10.1001/archopht.1962.00960020476016.
8
Thyroidal hormones restore cell proliferation to the lenses of hypophysectomized adult frogs.
Gen Comp Endocrinol. 1980 Mar;40(3):268-74. doi: 10.1016/0016-6480(80)90275-0.
9
The lens epithelium and radiation cataracts. II. Interphase death in the meridional rows?晶状体上皮与放射性白内障。II. 子午线行中的间期死亡?
Radiat Res. 1980 Oct;84(1):115-121.
10
A comparison of growth regulation of mammalian with amphibian lens epithelium.
Lens Eye Toxic Res. 1989;6(4):675-86.

引用本文的文献

1
Identification and quantification of ionising radiation-induced oxysterol formation in membranes of lens fibre cells.晶状体纤维细胞膜中电离辐射诱导的氧化甾醇形成的鉴定与定量分析。
Adv Redox Res. 2023 Apr;7:None. doi: 10.1016/j.arres.2022.100057.
2
Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape.非线性电离辐射引起的眼晶状体细胞增殖、细胞周期蛋白D1表达及晶状体形状的变化。
Open Biol. 2015 Apr;5(4):150011. doi: 10.1098/rsob.150011.
3
Ionizing irradiation not only inactivates clonogenic potential in primary normal human diploid lens epithelial cells but also stimulates cell proliferation in a subset of this population.

本文引用的文献

1
Whole mounts of rabbit lens epithelium for cytological study.用于细胞学研究的兔晶状体上皮整装片。
Stain Technol. 1952 Nov;27(6):313-5. doi: 10.3109/10520295209105094.
2
Mitotic variations in the lens epithelium of the frog IV. Studies with isolated anuran pituitary factors.青蛙晶状体上皮细胞的有丝分裂变异IV. 对分离出的无尾两栖类垂体因子的研究
Growth. 1976 Dec;40(4):317-28.
3
Mitotic variations in the lens epithelium of the frog. III. Somatotropin.青蛙晶状体上皮细胞的有丝分裂变化。III. 生长激素。
电离辐射不仅会使原代正常人二倍体晶状体上皮细胞的克隆形成能力失活,还会刺激该细胞群体中一部分细胞的增殖。
PLoS One. 2014 May 19;9(5):e98154. doi: 10.1371/journal.pone.0098154. eCollection 2014.
4
Emerging issues in radiogenic cataracts and cardiovascular disease.放射性白内障和心血管疾病中的新问题。
J Radiat Res. 2014 Sep;55(5):831-46. doi: 10.1093/jrr/rru036. Epub 2014 May 13.
5
The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens.抑癌基因 Trp53 可保护小鼠晶状体免受后囊下白内障的影响,BMP 受体 Acvr1 在晶状体中充当抑癌基因。
Dis Model Mech. 2011 Jul;4(4):484-95. doi: 10.1242/dmm.006593. Epub 2011 Apr 18.
6
Experimental radiation cataract--its clinical relevance.实验性放射性白内障——其临床相关性
Bull N Y Acad Med. 1983 May;59(4):372-92.
Gen Comp Endocrinol. 1975 Jan;25(1):52-9. doi: 10.1016/0016-6480(75)90038-6.
4
Lens epithelium and radiation cataract. I. Preliminary studies.晶状体上皮与放射性白内障。I. 初步研究。
Arch Ophthalmol. 1976 Jun;94(6):996-9. doi: 10.1001/archopht.1976.03910030506013.
5
Human posterior subcapsular cataract. A gross and flat preparation study.人类后囊下白内障。大体标本及平铺标本研究。
Arch Ophthalmol. 1978 Sep;96(9):1653-8. doi: 10.1001/archopht.1978.03910060279020.