Norris D A, Weston W L, Tubergen D G, Rose B, Odom L F
J Lab Clin Med. 1980 Apr;95(4):609-15.
Monocyte chemotaxis was studied in 35 patients with ALL, six with CLL, six with AML, and 10 with CML before beginning chemotherapy. Function was contrasted to age-matched control groups. Significant inhibition of chemotaxis was seen in patients with ALL (p less than 0.001) and CLL (p less than 0.01), whereas function in CML and AML patients was not significantly depressed. The deficient monocyte chemotaxis was not due merely to decreased percentages of peripheral blood monocytes. Thus, in addition to numerical deficiencies in monocyte numbers, qualitative deficiencies in monocyte function exist in patients with ALL and CLL.
在开始化疗前，对35例急性淋巴细胞白血病（ALL）患者、6例慢性淋巴细胞白血病（CLL）患者、6例急性髓细胞白血病（AML）患者和10例慢性髓细胞白血病（CML）患者的单核细胞趋化性进行了研究。将其功能与年龄匹配的对照组进行对比。ALL患者（p<0.001）和CLL患者（p<0.01）的趋化性受到显著抑制，而CML和AML患者的功能未受到明显抑制。单核细胞趋化性不足不仅仅是由于外周血单核细胞百分比降低所致。因此，除了单核细胞数量的数值不足外，ALL和CLL患者还存在单核细胞功能的质性不足。
