Kotzin B L, Strober S
Science. 1980 Apr 4;208(4439):59-61. doi: 10.1126/science.6965803.
A spontaneous B cell leukemia (BCL1) grew progressively in normal BALB/c mice after injection of tumor cells but did not grow in splenectomized recipients. Despite the absence of progressive tumor growth, residual tumor cells with malignant potential were found in the peripheral blood of the splenectomized animals. Splenectomy performed after injection of tumor cells but before the development of marked leukocytosis also prevented progressive tumor growth and death of the host. Thus the spleen appears to be necessary for progressive proliferation of this lymphocytic leukemia early after passage in vivo.
一种自发性B细胞白血病（BCL1）在向正常BALB/c小鼠注射肿瘤细胞后会逐渐生长，但在脾切除的受体小鼠中不会生长。尽管没有肿瘤的渐进性生长，但在脾切除动物的外周血中发现了具有恶性潜能的残留肿瘤细胞。在注射肿瘤细胞后但在明显的白细胞增多症出现之前进行脾切除术，同样可以阻止肿瘤的渐进性生长和宿主死亡。因此，脾脏似乎是这种淋巴细胞白血病在体内传代后早期进行性增殖所必需的。
