Hsieh K H
Ann Allergy. 1980 Mar;44(3):177-80.
Distributions of T-cell subpopulations before and after in vitro allergen stimulation were studied in 57 house dust sensitive asthmatic children and 23 healthy persons. House dust sensitivity was defined by both positive skin test and RAST, T micron cells were detected by rosette formation of T-cells with ox RBC-IgM complexes and T gamma cells with ox RBC-IgG complexes. Without stimulation there was no difference in the distribution of T micron and T gamma cells between patients and normals. After stimulation, while both T micron and T gamma cells were increased in patients, only T gamma cells were increased in normals. Therefore, the normal IgE response of healthy individuals to allergen exposure may result from enhanced T gamma suppressor cells.
对57名对屋尘敏感的哮喘儿童和23名健康人研究了体外变应原刺激前后T细胞亚群的分布情况。通过皮肤试验阳性和放射变应原吸附试验（RAST）来定义屋尘敏感性，用T细胞与氧化红细胞 - IgM复合物形成玫瑰花结来检测Tμ细胞，用T细胞与氧化红细胞 - IgG复合物形成玫瑰花结来检测Tγ细胞。在未受刺激时，患者和正常人之间Tμ和Tγ细胞的分布没有差异。刺激后，患者的Tμ和Tγ细胞均增加，而正常人仅Tγ细胞增加。因此，健康个体对变应原暴露的正常IgE反应可能是由增强的Tγ抑制细胞所致。
