Hsieh K H
Ann Allergy. 1980 Aug;45(2):104-7.
The T-cell regulations of IgG and IgE biosynthesis were studied by treating purified T-cells from normal adult and asthmatic patients with various concentrations of concanavalin A (Con A) and the co-cultivated with allogeneic mononuclear cells in the presence of pokeweed mitogen for seven days. After being treated with 20 microgram/ml or more of Con A for 18 hours, T-cells from both normal and allergic individuals were able to suppress IgG, but not IgE, production of allogeneic lymphocytes. The results suggest that the T-cell regulation of IgE production is different from that of IgG synthesis and allergic patients do retain suppressor T-cell function(s).
通过用不同浓度的伴刀豆球蛋白A（Con A）处理来自正常成年人和哮喘患者的纯化T细胞，并在有商陆有丝分裂原存在的情况下与同种异体单核细胞共培养7天，研究了T细胞对IgG和IgE生物合成的调节作用。用20微克/毫升或更高浓度的Con A处理18小时后，来自正常人和过敏个体的T细胞均能够抑制同种异体淋巴细胞的IgG产生，但不能抑制IgE产生。结果表明，T细胞对IgE产生的调节不同于对IgG合成的调节，并且过敏患者确实保留了抑制性T细胞功能。
