类风湿关节炎中淋巴细胞向变性I型胶原和B淋巴细胞同种抗原的转化
Lymphocyte transformation to denatured type I collagen and B lymphocyte alloantigens in rheumatoid arthritis.
作者信息
Smolen J S, Menzel E J, Scherak O, Kojer M, Kolarz G, Steffen C, Mayr W R
出版信息
Arthritis Rheum. 1980 Apr;23(4):424-31. doi: 10.1002/art.1780230405.
Peripheral blood lymphocytes transformed significantly to denatured type I collagen in 22 of 38 patients with rheumatoid arthritis (58%), 1 of 9 patients with Reiter's disease (P less than 0.05), and 9 of 32 controls (28%) (P less than 0.01). Determination of HLA antigens revealed significant differences between 24 rheumatoid arthritis (RA) patients and a control population for HLA-DRw4 (75% versus 23%). No correlation was observed between lymphocyte transformation to collagen and antibodies to collagen, rheumatoid factor, stage or duration of RA, or HLA antigens.
在38例类风湿性关节炎患者中，22例（58%）的外周血淋巴细胞对变性I型胶原发生显著转化；在9例赖特综合征患者中，1例出现这种情况（P<0.05）；在32例对照者中，9例（28%）出现这种情况（P<0.01）。HLA抗原测定显示，24例类风湿性关节炎（RA）患者与对照人群在HLA-DRw4方面存在显著差异（分别为75%和23%）。未观察到淋巴细胞对胶原的转化与抗胶原抗体、类风湿因子、RA的分期或病程以及HLA抗原之间存在相关性。
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