利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.
作者信息
Hirai Y, Nisonoff A
出版信息
J Exp Med. 1980 May 1;151(5):1213-31. doi: 10.1084/jem.151.5.1213.
Abstract
Evidence is presented for the selective suppression of the major idiotypic component of the humoral response to the phenylarsonate hapten by soluble factors derived from T cells (TsF). The existence of TsF with anti-idiotypic receptors was also demonstrated. It was found that TsF with idiotypic and anti-idiotypic receptors coexist in cultures of spleen cells prepared from idiotypically suppressed, hyperimmunized mice. By gel filtration the molecular weight of each factor was found to be 50,000-100,000. Each is sensitive to trypsin and is bound to a column containing anti-H-2a antibodies. Evidence is discussed which suggests the possibility of mutual stimulation of suppressor T cells with idiotypic and anti-idiotypic receptors.
摘要
有证据表明，来自T细胞的可溶性因子（TsF）可选择性抑制针对苯胂酸半抗原的体液反应中的主要独特型成分。还证实了具有抗独特型受体的TsF的存在。研究发现，具有独特型和抗独特型受体的TsF共存于由独特型抑制的、经超免疫的小鼠制备的脾细胞培养物中。通过凝胶过滤发现每个因子的分子量为50,000 - 100,000。每个因子对胰蛋白酶敏感，并与含有抗H - 2a抗体的柱结合。文中讨论了相关证据，这些证据提示了具有独特型和抗独特型受体的抑制性T细胞相互刺激的可能性。
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Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
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2
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3
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4
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5
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7
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8
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