对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。IX. 体外针对空斑形成细胞应答的独特型特异性效应期抑制细胞的特性
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. IX. Characterization of Idiotype-specific effector-phase suppressor cells on plaque-forming cell responses in vitro.
作者信息
Sherr D H, Dorf M E
出版信息
J Exp Med. 1981 Jun 1;153(6):1445-56. doi: 10.1084/jem.153.6.1445.
Abstract
The ability of T suppressor cells, induced by the intravenous injection of 4-hydroxy-3-nitrophenyl acetyl (NP)-modified syngeneic spleen cells, to affect an ongoing B cell response was studied in vitro. It was found that the expression of NPb idiotype-positive B cells could be selectively inhibited by the addition of antigen-induced suppressor cells in the last 24 h of the in vitro culture. This effector-phase suppression of B cell responses was antigen specific and mediated by an Lyt 1-, Lyt 2+, idiotype-binding, T cell population whose suppressive function was restricted by genes linked to the Igh locus.
摘要
通过静脉注射4-羟基-3-硝基苯基乙酰（NP）修饰的同基因脾细胞诱导的抑制性T细胞影响正在进行的B细胞反应的能力在体外进行了研究。结果发现，在体外培养的最后24小时加入抗原诱导的抑制细胞可选择性抑制NPb独特型阳性B细胞的表达。B细胞反应的这种效应期抑制是抗原特异性的，由Lyt 1-、Lyt 2+、独特型结合的T细胞群体介导，其抑制功能受与Igh基因座连锁的基因限制。
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Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VII. Idiotype-specific suppression of plaque-forming cell responses.对半抗原4-羟基-3-硝基苯乙酰的特异性T细胞应答。VII. 独特型特异性对空斑形成细胞应答的抑制作用
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Selective suppression of the major idiotypic component of an antihapten response by soluble T cell-derived factors with idiotypic or anti-idiotypic receptors.利用具有独特型或抗独特型受体的可溶性T细胞衍生因子选择性抑制抗半抗原反应的主要独特型成分。
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Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. III. Interaction of effector suppressor T cells is restricted by H-2 and Igh-V genes.对半抗原4-羟基-3-硝基苯乙酰的半抗原特异性T细胞应答。III. 效应性抑制性T细胞的相互作用受H-2和免疫球蛋白重链可变区（Igh-V）基因的限制。
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Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors.抗原和受体驱动的调节机制。IV. 携带独特型的I-J+抑制性T细胞因子诱导表达抗独特型受体的二级抑制性T细胞。
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