神经系统疾病中的脑脊液补体蛋白

Cerebrospinal fluid complement proteins in neurological disease.

作者信息

Price P, Cuzner M L

出版信息

J Neurol Sci. 1980 Apr;46(1):49-54. doi: 10.1016/0022-510x(80)90042-8.

Abstract

CSF levels of C3 and C4 were similar in patients with no neurological disease, minor non-inflammatory conditions, degenerative disease and MS during relapse, but slightly lower in MS during remission and higher in patients with inflammation. All MS patients had low CSF levels of alpha 1-antitrypsin and high levels of IgG. The roles of local production and consumption of complement protein and damage to the blood-brain barrier are discussed.

摘要

在无神经系统疾病、轻度非炎症性疾病、退行性疾病以及复发期多发性硬化症患者中，脑脊液中C3和C4水平相似，但在缓解期多发性硬化症患者中略低，而在炎症患者中则较高。所有多发性硬化症患者的脑脊液中α1 -抗胰蛋白酶水平较低，IgG水平较高。文中讨论了补体蛋白的局部产生和消耗以及血脑屏障损伤的作用。