多发性硬化症的良性病程与脑脊液中低度体液免疫反应之间的关系。
Relation between benign course of multiple sclerosis and low-grade humoral immune response in cerebrospinal fluid.
作者信息
Stendahl-Brodin L, Link H
出版信息
J Neurol Neurosurg Psychiatry. 1980 Feb;43(2):102-5. doi: 10.1136/jnnp.43.2.102.
Abstract
The prognosis in multiple sclerosis (MS) is related to the presence of an abnorma humoral immune response within the central nervous system: 14/17 MS patients (82%) without oligoclonal CSF IgG displayed no or slight disability after a mean duration of MS of 17 years, while 53% of 88 patients with oligoclonal CSF IgG had a benign course after a mean duration of 13 years (p less than 0.05). A benign course also was more often accompanied by a normal CSF IgG index. MS patients without oligoclonal CSF IgG had elevated CSF/serum ratios of albumin in 6%, and of the complement factors C3 in 0% and C4 in 6%, as against 20%, 27% and 37%, respectively, in MS patients with oligoclonal CSF IgG.
摘要
多发性硬化症（MS）的预后与中枢神经系统内异常体液免疫反应的存在有关：17例无寡克隆脑脊液IgG的MS患者中，14例（82%）在MS平均病程17年后无残疾或仅有轻微残疾，而88例有寡克隆脑脊液IgG的患者中，53%在平均病程13年后病程呈良性（p<0.05）。良性病程也更常伴有脑脊液IgG指数正常。无寡克隆脑脊液IgG的MS患者中，脑脊液/血清白蛋白比率升高的占6%，补体因子C3升高的占0%，C4升高的占6%，而有寡克隆脑脊液IgG的MS患者中，上述比率分别为20%、27%和37%。
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